Metoprolol succinate (Toprol-XL) belongs to a group of drugs called beta-blockers. Doctors commonly prescribe this drug to treat high blood pressure, heart failure and heart-related chest pain called angina. Metoprolol succinate ER is a long-acting, once daily form of metoprolol. A wide variety of side effects are possible with metoprolol succinate, ranging from nausea and fatigue to potentially serious heart rhythm abnormalities and shortness of breath. The 50-mg dose of metoprolol succinate ER is a mid-range amount. Side effects might be more common with higher doses. The most common side effects of metoprolol succinate relate to its actions as a beta-blocker. It prevents the hormone adrenaline from binding to matching receptors in the brain, heart, blood vessels and kidneys. cipro fda Trust in 4 dosage strengths to suit your patient’s needs TOPROL-XL and its authorized generic, metoprolol succinate (distributed by Lannett Company, Inc.), are available in 4 dosage strengths—25 mg, 50 mg, 100 mg, and 200 mg.* Available in identical dosing options for the authorized generic of TOPROL-XL— 25 mg, 50 mg, 100 mg, and 200 mg* multicenter, randomized, double-blind, placebo-controlled, parallel-group, unbalanced factorial study. In part, it evaluated the antihypertensive efficacy and the safety of once-daily dosing with extended-release metoprolol succinate monotherapy and placebo in adult patients with newly diagnosed or treated essential hypertension. Tamoxifen for infertility Propecia dose DOSAGE AND ADMINISTRATION. TOPROL-XL is an extended-release tablet intended for once daily administration. For treatment of hypertension and angina, when switching from immediate-release metoprolol to TOPROL-XL, use the same total daily dose of TOPROL-XL. metformin dosage TOPROL-XL® metoprolol succinate is available in 4 dosage strengths—25 mg, 50 mg, 100 mg, and 200 mg. If you have high blood pressure, your doctor may. Metoprolol tartrate and metoprolol succinate both carry a boxed warning, the most serious warning from the FDA. The FDA warns that either drug may cause worse chest pain or a heart attack if you. Switching from immediate-release to extended-release: Use same total daily dose of metoprolol Switching between oral and IV dosage forms: Equivalent beta-blocking effect is achieved in 2.5:1 (oral-to-IV) ratio Dizziness (10%) Headache (10%) Tiredness (10%) Depression (5%) Diarrhea (5%) Pruritus (5%) Bradycardia (9%) Rash (5%) Dyspnea (1-3%) Cold extremities (1%) Constipation (1%) Dyspepsia (1%) Heart failure (1%) Hypotension (1%) Nausea (1%) Flatulence (1%) Heartburn (1%) Xerostomia (1%) Wheezing (1%) Bronchospasm (1%) Anxiety/nervousness Hallusinations Paresthesia Hepatitis Vomiting Arthralgia Male impotence Reversible alopecia Agranulocytosis Dry eyes Worsening of psoriasis Pyronie’s disease Sweating Photosensitivity Taste disturbance Lopressor and Toprol XL only Ischemic heart disease may be exacerbated after abrupt withdrawal Hypersensitivity to catecholamines has been observed during withdrawal Exacerbation of angina and, in some cases, myocardial infarction (MI) may occur after abrupt discontinuance When long-term beta blocker therapy (particularly with ischemic heart disease) is discontinued, dosage should be gradually reduced over 1-2 weeks with careful monitoring If angina worsens markedly or acute coronary insufficiency develops, beta-blocker administration should be promptly reinitiated, at least temporarily (in addition to other measures appropriate for unstable angina) Patients should be warned against interruption or discontinuance of beta-blocker therapy without physician advice Because coronary artery disease (CAD) is common and may be unrecognized, beta-blocker therapy must be discontinued slowly, even in patients treated only for hypertension Use with caution in cerebrovascular insufficiency, CHF, cardiomegaly, myasthenia gravis, hyperthyroidism or thyrotoxicosis (may mask signs or symptoms), liver disease, renal impairment, peripheral vascular disease, psoriasis (may cause exacerbation of psoriasis) May exacerbate bronchospastic disease; monitor closely Beta blockers can cause myocardial depression and may precipitate heart failure and cardiogenic shock Sudden discontinuance can exacerbate angina and lead to MI and ventricular arrhythmias in patients with CAD Worsening cardiac failure may occur during up-titration of metoprolol succinate; if such symptoms occur, increase diuretics and restore clinical stability before advancing the dose of metoprolol succinate; it may be necessary to lower the dose of metoprolol succinate or temporarily discontinue it Bradycardia, including sinus pause, heart block, and cardiac arrest, has been reported; patients with 1° atrioventricular block, sinus node dysfunction, or conduction disorders may be at increased risk Increased risk of stroke after surgery May potentiate hypoglycemia in patients with diabetes mellitus and may mask signs and symptoms Avoid starting high-dose regimen of extended-release metoprolol in patients undergoing noncardiac surgery; use in patients with cardiovascular risk factors is associated with bradycardia, hypotension, stroke, and death Long-term beta blockers should not be routinely withdrawn before major surgery; however, impaired ability of the heart to respond to reflex adrenergic stimuli may augment risks of general anesthesia and surgical procedures Metoprolol loses beta-receptor selectivity at high doses and in poor metabolizers If drug is administered for tachycardia secondary to pheochromocytoma, it should be given in combination with an alpha blocker (which should be started before metoprolol is started) While taking beta blockers, patients with history of severe anaphylactic reaction to variety of allergens may be more reactive to repeated challenge Extended release tablet should not be withdrawn routinely prior to major surgery Hydrochlorothiazide, can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma, which can lead to permanent vision loss if not treated; discontinue hydrochlorothiazide as rapidly as possible if symptoms occur; prompt medical or surgical treatments may need to be considered if intraocular pressure remains uncontrolled; risk factors for developing acute angle-closure glaucoma may include history of sulfonamide or penicillin allergy Caution in patients with history of psychiatric illness; may cause or exacerbate CNS depression Beta-blockers can precipitate or aggravate symptoms of arterial insufficiency in patients with peripheral vascular disease There are no adequate and well-controlled studies in pregnant women Limited data on the use of metoprolol in pregnant women Risk to fetus/mother is unknown; because animal reproduction studies are not always predictive of human response, use if clearly needed Bioavailability: 40-50% (immediate-release) ; 65-77% (extended-release) relative to immediate release Onset: 20 min (IV), when infused over 10 min; onset may be immediate, depending on clinical setting; 1-2 hr (PO) Duration: 3-6 hr (PO); duration is dose-related; 24 hr (ER); 5-8 hr (IV) Peak plasma time: 1.5-2 hr (immediate-release); 3.3 hr (extended-release) Therapeutic range: 35-212 ng/m L The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. The recommended starting dosage of metoprolol succinate for people with high blood pressure (hypertension) is 25 mg to 100 mg once a day. After a week or more, based on the blood pressure response and/or metoprolol succinate side effects, the metoprolol succinate dosage may be increased or decreased. Your healthcare provider may also add a diuretic (a "water pill") or another blood pressure medication if your blood pressure is not controlled by metoprolol succinate alone. The recommended starting dosage of metoprolol succinate for people with angina is 100 mg once a day. After one week, based on the response and/or side effects, the metoprolol succinate dosage may be increased or decreased. Your metoprolol succinate dose may continue to be increased until your angina symptoms improve, until you develop bothersome or intolerable side effects, or until the maximum daily dose of 400 mg per day is reached. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Metoprolol succinate dosage Metoprolol Succinate - FDA prescribing information, side., Dosing for TOPROL-XL metoprolol succinate and How to Take. Zoloft price australia To deliver metoprolol continuously over the dosage interval. The tablets contain 23.75, 47.5, 95 and. 190 mg of metoprolol succinate equivalent to 25, 50, 100. Metoprolol succinate - FDA Metoprolol Tartrate vs. Metoprolol Succinate A Comparison Toprol-XL metoprolol succinate dose, indications, adverse effects. Metoprolol Succinate official prescribing information for healthcare professionals. Includes indications, dosage, adverse reactions, pharmacology and more. propranolol hydrochloride tablet Desvenlafaxine Moderate Decrease the metoprolol dose by up to one-half when coadministered with desvenlafaxine 400 mg/day; resume original metoprolol dose if desvenlafaxine 400 mg/day is discontinued. No dosage adjustment is necessary when metoprolol is coadministered with desvenlafaxine 100 mg/day or lower. List Metoprolol Succinate side effects by likelihood and severity. Find Lowest Prices. Read More. Precautions. Precautions. Before taking metoprolol, tell your doctor or pharmacist if you are.