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    Erythromycin belongs to a group of drugs known as macrolides. Azithromycin and clarithromycin are better than erythromycin at reaching the lungs and respiratory tract, and thus are preferred for respiratory tract infections. The activity of macrolides stems from the presence of a macrolide ring, a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Clindamycin are more effective than erythromycin for treatment of infections caused by anaerobic bacteria (ones that grow in the absence of oxygen) (Ross-Flanigan and Uretsky 2005). Macrocyclic refers to a cyclic macromolecule or macromolecular cyclic portion of a molecule, commonly any molecule with a ring of more than nine. The mechanism of action of the macrolides is inhibition of bacterial protein biosynthesis by binding reversibly to the subunit 50S of the bacterial ribosome, thereby inhibiting translocation of peptidyl t RNA. The lactone rings of macrolides are usually 14, 15 or 16-membered. This action is mainly bacteriostatic (hampers the growth of bacteria), but can also be bactericidal (kills bacteria) in high concentrations. In structure, erthyromycin is a macrocyclic compound containing a 14-membered lactone ring with ten asymmetric centers and two sugars (. Macrolides tend to accumulate within leukocytes, and are therefore actually transported into the site of infection. By binding to the 50S subunit of the bacterial 70S r RNA complex, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited (Trevor et al. Erythromycin interferes with aminoacyl translocation, preventing the transfer of the t RNA bound at the A site of the r RNA complex to the P site of the r RNA complex. Erythromycin is available in enteric-coated tablets, slow-release capsules, oral suspensions, ophthalmic solutions, ointments, gels, and injections. Likewise, erythromycin may possess bacteriocidal activity, particularly at higher concentrations (Trevor et al. Without this translocation, the A site remains occupied and thus the addition of an incoming t RNA and its attached amino acid to the nascent polypeptide chain is inhibited. It is manufactured and distributed by Eli Lilly and Company. This interferes with the production of functionally useful proteins and is therefore the basis of antimicrobial action. Азитромицин — Википедия viagra ad Azithromycin Monohydrate C38H74N2O13 - PubChem Azithromycin Health and Medicine Wiki FANDOM powered by Wikia
     
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