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    Kalydeco tablets are indicated for the treatment of patients with cystic fibrosis (CF) aged 6 years and older and weighing 25 kg or more who have one of the following gating (class III) mutations in the CFTR gene: G551D, G1244E, G1349D, G178R, G551S, S1251N, S1255P, S549N or S549R (see sections 4.4 and 5.1). Kalydeco tablets are also indicated for the treatment of patients with cystic fibrosis (CF) aged 18 years and older who have an R117H mutation in the CFTR gene (see sections 4.4 and 5.1). Kalydeco tablets are also indicated in a combination regimen with tezacaftor 100 mg/ivacaftor 150 mg tablets for the treatment of patients with cystic fibrosis (CF) aged 12 years and older who are homozygous for the F508del mutation or who are heterozygous for the F508del mutation and have one of the following mutations in the CFTR gene: P67L, R117C, L206W, R352Q, A455E, D579G, 711 3A→G, S945L, S977F, R1070W, D1152H, 2789 5G→A, 3272-26A→G, and 3849 10kb C→T. Kalydeco should only be prescribed by physicians with experience in the treatment of cystic fibrosis. If the patient's genotype is unknown, an accurate and validated genotyping method should be performed before starting treatment to confirm the presence of an indicated mutation in the CFTR gene (see section 4.1). The phase of the poly-T variant identified with the R117H mutation should be determined in accordance with local clinical recommendations. The recommended dose for adults, adolescents, and children aged 6 years and older and weighing 25 kg or more is one Kalydeco150 mg tablet taken orally every 12 hours (300 mg total daily dose) with fat-containing food (see Method of administration). Fluconazole MedlinePlus Drug Information best viagra and cialis FLUCONAZOL BASICS 150 mg Hartkapseln PZN 296590. Fluconazole -
     
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