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    The present invention relates to pharmaceutical composition for oral administration comprising sertraline or pharmaceutically acceptable salts thereof in which the sertraline hydrochloride has a particle size of d? PCT application WO 03/93217 discloses a tablet of sertraline hydrochloride and the following excipients, in weight to weight percentages, wherein the tablet is prepared from an industrial sized batch of sertraline hydrochloride Form II substantially free of sertraline hydrochloride Form I: about 20% to about 35% sertraline hydrochloride Form II, about 25% to about 40% lactose monohydrate, about 5% to about 12% croscarmellose sodium NF, about 1% to about 3% povidone, about 20% to about 40% microcrystalline cellulose and about 0.5% to about 2.5% magnesium stearate. 90#191 ranging from about 20 µm to about 40 µm and of d? The composition is bioequivalent to a reference pharmaceutical composition. The highly pure sertraline hydrochloride Form II used for preparing a tablet has a particle size distribution such that 100% of the particles are below 200 microns, more preferably below 100 microns and most preferably below about 50 microns. ORAL DOSAGE FORMS OF SERTRALINE HAVING CONTROLLED PARTICLE SIZE AND PROCESSES FOR THEIR PREPARATION Technical Field of the Invention The present invention relates to pharmaceutical compositions for oral administration that include sertraline or its pharmaceutically acceptable salts having a particle size of d ranging from about 5 μm to about 15 μm and wherein the composition is bioequivalent to a reference composition. The reduction in particle size of a drug so as to increase the surface area available for absorption is a commonly used practice in the realm of pharmaceutical sciences. The present invention also relates to processes for their preparation. A reduced particle size is known to enhance dissolution and absorption of the drug from an oral dosage form. Background of the Invention Sertraline, or (l S-cis)-4-(3,4-dichlorophenyl)-l,2,3,4-tetrahydro-N-methyl-l- naphthylenamine, is a therapeutically potent selective serotonin reuptake inhibitor. 4,536,518 which describes the synthesis of certain cis- 4-phenyl-l,2,3,4-tetrahydronaphthalenamine derivatives, including sertraline, and pharmaceutically acceptable salts of these compounds. 4,777,288; 4,839,104; 4,855,500; 5,463,126; 5,442,116; 5,082,970; 5,466,880; 5,196,607; 5,750,794; 5,288,916; and 6,323,500; as well as in the following published patent applications: International PCT Patent Publication No. However, such an increase in the rate and adsorption still cannot ensure that the dosage form is bioequivalent to a reference dosage form. Sertraline is commercially sold as its hydrochloride salt under the trademark Zoloft and is approved by the U. Food and Drug Administration for the treatment of depression, obsessive-compulsive disorder, posttraumatic stress disorder and panic disorder. Further methods of preparing sertraline are set forth in U. We have surprisingly found that pharmaceutical compositions comprising sertraline or its pharmaceutically acceptable salts, which are bioequivalent to the marketed preparation, may be prepared by controlling the particle size of sertraline, more particularly by using a finer particle size. Both of the above patents also disclose certain dry solid pharmaceutical composition prepared by blending sertraline with conventional ingredients used in tablet and capsule manufacturing. Sertraline Oral Route Proper Use - Mayo Clinic azithromycin used for bronchitis Sertraline Side Effects, Dosage, Uses & More - Healthline ZOLOFT® sertraline HCl Dosage and Administration Pfizer.
     
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