Chloroquine stability in water

Discussion in 'Plaquenil' started by Kvieksheks, 19-Mar-2020.

  1. bergus XenForo Moderator

    Chloroquine stability in water


    The effects of light at wavelengths of 240–600 nm on solutions of chloroquine in isopropanol, and of light at wavelenghts of 320–600 nm on solutions of chloroquine in buffer solutions were investigated. Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it.

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    Chloroquine phosphate is freely soluble in water, but poorly soluble in isopropanol. To obtain a sufficient concentration of chloroquine in isopropanol, chloroquine base was used. The base was isolated from an aqueous solution at pH 11 by extraction with chloroform. Oct 30, 2019 Hydroxychloroquine can be detected in the cord blood at delivery in concentrations similar to those in the maternal serum Costedoat-Chalumeau 2002. In animal reproduction studies with chloroquine, accumulation in fetal ocular tissues was observed and remained for several months following drug elimination from the rest of the body. Chloroquine CAS NO.54-05-7 is stability stable, but light sensitive. It is incompatible with strong oxidizing agents. It is soluble in water, insoluble in alcohol, chloroform and ether.

    It is recommended to check if chloroquine is still effective in the region prior to using it. Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance.

    Chloroquine stability in water

    Chloroquine - DrugFuture, Hydroxychloroquine Professional Patient Advice -

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  7. Deoxoartelinic acid also showed remarkable stability with a half-life of 258.66 h, 23 times more stable than clinically useful arteether in simulated stomach acid, and improved solubility, 4 times more soluble than artemisinin in water.

    • Synthesis, Stability, and Antimalarial Activity of New..
    • Chloroquine supplier CasNO.54-05-7.
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    Tonic water was never intended as a cure or preventive for malaria, but malaria is the reason the quinine is in there. Quinine has a bitter taste. To make the stuff palatable when used as an antidote for fevers, legend has it, British colonials in India mixed quinine with gin and lemon or lime. Over time they learned to love the godawful stuff. The solubilities of chloroquine diphosphate and 4,7-dichloroquinoline in water, ethanol, tetrahydrofuran, acetone, and acetonitrile were measured over the temperature range of 298.2 to 333.2 K. Hydroxychloroquine HCQ is a 4-aminoquinoline that differs from chloroquine CQ by the addition of a hydroxyl group. It was first synthesized in 1944 and initially used as an antimalarial agent.

     
  8. LokaFinn Well-Known Member

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  9. Tranzit Moderator

    Comparative study of chloroquine and quinine on malaria. The life cycle is similar to another malaria parasite of mammals8. The study on the rodent's malaria can be a good model of human malaria infection. Quinine is an antimalarial drug which is made from Cinchona bark9. The mode of action of quinine is similar to chloroquine.

    Malaria - Medical Microbiology - NCBI Bookshelf