Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties. Hydroxychloroquine sun allergy Plaquenil side effects bleeding As shown in preclinical models, inhibition of autophagy restored chemosensitivity and enhanced tumor cell death. These results established autophagy as a therapeutic target and led to multiple early phase clinical trials in humans to evaluate autophagy inhibition using hydroxychloroquine in combination with chemotherapy or targeted agents. Resistance, and the use of autophagy inhibitors, including chloroquine CQ or hydroxychloroquine HCQ Figure 1, can reverse this eﬀect. While most reports have found that autophagy inhibition restores and/or enhances the sensitivity of the tumor cells to chemotherapy, as in tumorigenesis, the consequences of drug- Autophagy inhibition with chloroquine CQ derivatives augments the efﬁcacy of many anticancer therapies, but CQ has limited activity as a single agent. Clinical trials are underway combining anticancer agents with hydroxychloroquine HCQ, but concen-trations of HCQ required to inhibit autophagy are not consistently achievable in the clinic. In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms). Autophagy inhibitors hydroxychloroquine Chloroquine & Hydroxychloroquine supporting chemo., Discovery of Autophagy Inhibitors with Antiproliferative Activity in. Plaquenil with valium Hydroxychloroquine HCQ, the analog of chloroquine, augments the effect of chemotherapies and radiotherapy on various tumors identified in the current clinical trials. Meanwhile, the toxicity of HCQ retinopathy raises concern worldwide. Thus, the potent autophagy inhibitors are urgently needed. A systematic review was related to ‘hydroxychloroquine’ or ‘chloroquine’ with ‘clinical. Research progress of hydroxychloroquine and autophagy.. Autophagy inhibitor Lys05 has single-agent antitumor.. Phase II and Pharmacodynamic Study of Autophagy Inhibition.. Hydroxychloroquine, a synthetic derivative of quinolyl, is a potent autophagy inhibitor. Hydroxychloroquine is a synthetic derivative of quinolyl. It increases the pH within intracellular vacuoles and alters processes such as protein degradation by acidic hydrolases, assembly of macromolecules, and post-translation modification of proteins Fox. Hydroxychloroquine PLAQUENILR is an orally available autophagy inhibitor that has been used for many years to treat autoimmune diseases like lupus, sarcoidosis and rheumatoid arthritis at the standard dosing of 400-600mg/day. Hydroxychloroquine Sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor TLR 7/9.