Relapse of plasmodium vivax after chloroquine

Discussion in 'Pharmacy Northwest Canada' started by Aspect, 11-Mar-2020.

  1. Katenok9112007 Well-Known Member

    Relapse of plasmodium vivax after chloroquine


    “Presumptive treatment” without the benefit of laboratory confirmation should be reserved for extreme circumstances (strong clinical suspicion or severe disease in a setting where prompt laboratory diagnosis is not available). Once the diagnosis of malaria has been made, appropriate antimalarial treatment must be initiated immediately.

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    Radical cure in P. vivax infection is, killing of exoerythrocytic stage of parasites known as hypnozoites, which are responsible for relapse of malaria. If only chloroquine or other agents for clinical cure is used, it will have no effects on hypnozoites and lead to recurrence of malaria again, later on, without new infection by mosquito bite. To prevent relapse of P. vivax malaria, radical cure agent most popular is primaquine is used. Vivax relapse periodicity, with regions of short relapse periodicity considered to have a median time to relapse of ≤ 47 days. To avoid confounding from early treatment failure, recurrence was defined as vivax parasitaemia between days 7 and 42. Jan 20, 2019 P. vivax also has the ability to lie dormant in the liver from where it periodically reactivates to cause relapses of P. vivax malaria. Hence, a single P. vivax infection can give rise to multiple episodes of malaria. The dormant liver forms of the parasite cannot be treated with most antimalarial treatments active against the blood-stage parasite.

    The clinical status of the patient: Patients diagnosed with malaria are generally categorized as having either uncomplicated or severe malaria. Treatment should be guided by three main factors: infections, the urgent initiation of appropriate therapy is especially critical.

    Relapse of plasmodium vivax after chloroquine

    Primaquine treatment and relapse in Plasmodium vivax malaria, The haematological consequences of Plasmodium vivax malaria.

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  3. Jun 22, 2012 A relapse was defined as a subsequent infection with no return travel to a malaria endemic country in the interval between first and subsequent episode, or P. vivax infection after receiving primaquine therapy as presumptive anti-relapse therapy PART, otherwise known as terminal prophylaxis.

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    Llanos-Cuentas A, Lacerda MV, Rueangweerayut R, et al. Tafenoquine plus chloroquine for the treatment and relapse prevention of Plasmodium vivax malaria DETECTIVE a multicentre, double-blind. Aug 05, 2019 Manufacturer Recommendations 15 mg base 26.3 mg salt orally once a day for 14 days. Comments Recommended only for the radical cure of vivax malaria, the prevention of relapse in vivax malaria, or after the end of chloroquine phosphate suppressive therapy in vivax malaria-endemic area. Treatment of Plasmodium vivax malaria requires the clearing of asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared from the liver a treatment termed “radical cure”. Tafenoquine is a single-dose 8-aminoquinoline that has recently been registered for the radical cure of P. vivax.

     
  4. lankoq User

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Hydroxychloroquine Oral Route Proper Use - Mayo Clinic Hydroxychloroquine MedlinePlus Drug Information Hydroxychloroquine Side Effects, Dosage, Uses, and More
     
  5. Garini4 Well-Known Member

    Hydroxychloroquine is a disease-modifying anti-rheumatic drug (DMARD). Alcohol & RA questions Arthritis Information Alcohol and Arthritis Medications Proton Pump Inhibitor PPI Interactions Drugs, Foods & Drinks
     
  6. vacik Guest

    Hydroxychloroquine Plaquenil Hydroxychloroquine typically is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness.

    Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses