Quinacrine hydrochloride also has the 4-amino quinoline radical but has, in addition, a benzene ring; it is classified as an acridine compound. The 4-amino quinoline radical is present in all antimalarial compounds shown to be effective in the treatment of lupus erythematosus (LE) (Figure). Plaquenil baseline examen Plaquenil and sjogren's syndrome Chloroquine and hydroxychloroquine have molecular weights of 320 and 336, respectively 26, 27. Both chloroquine and hydroxychloroquine are amphiphilic weak bases based on two fused aromatic rings having conjugated double bonds, the 4-aminoquinoline nucleus Fig. 2.1. Both drugs cross cell membranes well 16, 28, 29. Monitoring Hydroxychloroquine is the preferred antimalarial because it is less toxic to the eye. Chloroquine is sometimes tolerated by patients who do not tolerate hydroxychloroquine. Ophthalmologic retinal and visual field testing should be performed at baseline or soon after drug initiation and then at 6 -12 month intervals. Plaquenil hydroxychloroquine is a good choice for people who have difficulty tolerating newer biologic medications. A generic form of Plaquenil hydroxychloroquine is available. chloroquine is generally safe to use during pregnancy and for children. Its superiority over quinine was established during World War II, when it became the official drug for the treatment of malaria. Quinacrine was introduced for malaria therapy in 1930. Hydroxychloroquine vs chloroquine What Is the Difference between Hydroxychloroquine and., Hydroxychloroquine and Chloroquine Phosphate - RheumaKnowledgy Malaria treatment chloroquine how many dailyWhat company makes plaquenilPlaquenill oct maculaPlaquenil and shortness of breath Mar 15, 2019 Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. Chloroquine and Hydroxychloroquine Toxicity Practice.. Compare Plaquenil vs Chloroquine -. Plaquenil vs. Aralen Prescription Treatment for Malaria.. Plaquenil hydroxychloroquine is commonly used for lupus in children because of less side effects compared to other medications. Plaquenil hydroxychloroquine helps minimize joint damage. It can also decrease symptoms and future complications. Compare Chloroquine vs Hydroxychloroquine head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Chloroquine rated 10.0/10 vs Hydroxychloroquine rated 6.7/10 in overall patient satisfaction. Chloroquine toxicity remains a problem in many parts of the world, but is seen less frequently in the United States where the drug largely has been replaced by HCQ. Hydroxychloroquine is used widely for the treatment of systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatologic conditions.