It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Plaquenil for cancer Ara hydroxychloroquine Chloroquine prescription The Plaquenil is supposed to kick in in 3 to 6 months. I think it was 8 months for me. One day I was congratulating myself for getting so many things done and I realised that the days had been getting better without my noticing. In the beginning I also was on a low dose of prednisone, which helped until plaquenil kicked in. How long does it take for plaquenil hydroxychloroquine to work with rashes? Answers Follow Share. How long is it supposed to it take for plaquenil hydroxychloroquine to get rid of the lupus butterfly rash? 1 doctor responded I had a skin rash from plaquenil hydroxychloroquine. I was put on a 21 day taper of prednisone. For women, start with 100 pounds, and add 5 pounds for every inch over 5 feet. For men, start with 106 pounds, and add 6 pounds for every inch over 5 feet. The maximum dose of Plaquenil is 6.5 mg/kg of ideal body weight per day, regardless of whether a person is overweight, underweight, or normal weight. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. It may be as long as 12 weeks before you notice the benefits. Plaquenil how long to work Hydroxychloroquine Plaquenil, How long does it take for plaquenil hydroxychloroquine. Plaquenil for fibromyalgia reviewsOct plaquenil screeningChloroquine skin pigmentationIs hydroxychloroquine a sulfa drugHow much does hydroxychloroquine cost without insurance How Does Plaquenil Work For Rheumatoid Arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis or juvenile. How Does Plaquenil Work For Rheumatoid Arthritis. Protecting your eyesight when taking Plaquenil Lupus.. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. I'd like to report that I never have symtoms or flares anymore, but I do, but I think the Plaquenil makes the difference between being a sick person pre-plaquenil and a normal person who occationally feels sick. I was able to function again, as in go to work, after about a year and a half. Plaquenil takes quite a long time to get to its peak effectiveness depending on what you read, anywhere from 3 months to a year. Unless you are having significant side effects, try to give it at least 6 months before you decide it doesn't work for you. Someone else told me that plaquenil could take up to a year to work. Others have told me that it only took a few months for them to feel the effects. Everyone is different. I can tell you that plaquenil is the safest of all of the DMARDs. If you're going to stay on a DMARD for a long time, plaquenil is the one to be on. Best of luck on the plaquenil.