Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil sulfa Can you take xanax with plaquenil Chloroquine proguanil combination Plaquenil immunosuppression Hydroxychloroquine may not prevent malaria in all cases. especially if you take it for a long time. Get medical help right away if you have any very. rash, itching/swelling especially of. With the presistent spread of this hivey rash it sure makes it hard to believe that you will be able to continue the drug. The one thing that might help solve the problem is to stop the plaquenil. If you stop and the rash goes away in a logical period of time and then restart the drug only to have the rash come back. Bingo--you will know. Hydroxychloroquine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies, or to become more depressed. If you or your caregiver notice any of these side effects, tell your doctor right away. This medicine may cause hypoglycemia low blood sugar. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. How long for plaquenil rash to go away Hydroxychloroquine Side Effects Common, Severe, Long Term., Terrible Itching on Plaquenil---PLEASE HELP. Plaquenil seizurePlaquenil visual field screeningIs plaquenil porcine basedPeople on plaquenil Be patient. It is important that you always use sunscreen on this area and never to allow it to get sunburned. Additionally, consider seeing a dermatologist in another 5 weeks if the rash is not starting to get lighter. Even taking a picture and comparing every 4 weeks would give you a starting point. I had a skin rash from plaquenil hydroxychloroquine. I.. Hydroxychloroquine Oral Route Precautions - Mayo Clinic. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Aug 10, 2012 The plaquenil may or may not make the butterfly rash go away. There is no way to predict. Typically plaquenil takes 4 to 6 months to take full effect in controlling systemic lupus. It makes you a little less photosensitive as well. Please make sure you have a baseline field of vision test. It is just precautionary, but you do need a baseline. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Mild side effects may go away within a few days or a couple of weeks. Using this drug for a long. Plaquenil stays in your body for about 3 months. If you must stop it, it will take a while for the side effects to go away. You should have an eye examination every year to prevent a very rare but serious eye problem. Less than one person in 5,000 develops the problem.