Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. What does plaquenil do to the body Cat's claw and hydroxychloroquine Cutaneous lupus erythematosus CLE is an autoimmune, inflammatory skin disease seen in patients with or without systemic lupus erythematosus SLE. The management of CLE includes treatment and prevention of lesions, as well as routine assessment for systemic disease. Treatment options include both topical and systemic therapies. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. It is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. Adverse cutaneous reactions to hydroxychloroquine are more common in patients with dermatomyositis than in patients with cutaneous lupus erythematosus. Pelle MT1, Callen JP. Author information 1Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, USA. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine cutaneous lupus Treating Lupus with Anti-Malarial Drugs Johns Hopkins., Chloroquine - Wikipedia Hydroxychloroquine medlineplusPlaquenil sore moreResidul plaquenil in the eye Note that adverse cutaneous reactions to hydroxychloroquine are reported to affect more than 30% of patients with dermatomyositis, compared to a lower risk of rash in patients with cutaneous lupus erythematosus. If a rash appears, hydroxychloroquine should be withdrawn and may be restarted at a lower dose. Less common skin side effects may include Hydroxychloroquine DermNet NZ. Adverse cutaneous reactions to hydroxychloroquine are more.. How is plaquenil hydroxychloroquine used to treat lupus?. Chloroquine, which is made by one manufacturer in the US and was approved in the country in 1949, has been in shortage since March 9, according to the American Society of Health-System Pharmacists. Chloroquine has a particularly high affinity for melanin-containing cells and hence there are very high levels of chloroquine in the skin mainly, the epidermis and retina. Chloroquine has a long half-life, which can vary between 74 hours and 50 days, depending on the cumulative dose. The antimalarial agents chloroquine CQ and hydroxychloroquine HCQ are considered to be effective for the treatment of cutaneous lupus erythematosus CLE and the symptoms associated with systemic lupus erythematosus SLE such as rashes, joint pain, and fatigue.