Chloroquine primaquine

Discussion in 'International Pharmacy' started by Feoli, 22-Feb-2020.

  1. Ododiumma New Member

    Chloroquine primaquine


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    INTRODUCTION. Chloroquine, together with primaquine, has been the standard regimen for the radical cure of Plasmodium vivax and Plasmodium ovale malaria since the early 1950s 1, 2. Chloroquine is a highly effective schizontocide, while primaquine has weaker asexual-stage activity but is the only generally available drug with hypnozoitocidal properties, i.e. it kills dormant liver stage. Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. Primaquine is used after other medications such as chloroquine have killed the malaria parasites living inside red blood cells. Primaquine then kills the malaria parasites living in other body.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Chloroquine primaquine

    Primaquine C15H21N3O - PubChem, Chloroquine - Wikipedia

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  6. Infections should receive chloroquine prophylaxis 300 mg base po once a week during pregnancy. After delivery, patients with normal G6PD activity should be treated with primaquine or tafenoquine or continue with chloroquine prophylaxis for a total of 1 year. Primaquine can be used during breastfeeding if the infant is found

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    Primaquine phosphate is recommended only for the radical cure of vivax malaria, the prevention of relapse in vivax malaria, or following the termination of chloroquine phosphate suppressive therapy in an area where vivax malaria is endemic. Patients suffering from an attack of vivax Pada kasus tertentu, pemakaian chloroquine dikombinasikan dengan obat-obatan lain, seperti primaquine. Kombinasi tersebut umumnya diperlukan agar meningkatkan peluang kesembuhan sekaligus untuk mencegah kembalinya infeksi relaps. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. such as primaquine to kill the.

     
  7. lenok123 New Member

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Plaquenil Uses, Dosage & Side Effects - Will you have Breast cancer with Plaquenil - eHealthMe What Should Lupus Patients Know About Radiation Treatment.
     
  8. sanportals Moderator

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. CG10 - Putative chloroquine resistance transporter. How chloroquine works to treat malaria Menina Executiva Chloroquine Transport via the Malaria Parasite’s.
     
  9. Lulakebab XenForo Moderator

    Our brain tumor cocktails and stories Chloroquine for GBM. Jan 30, 2018 Stephen, I recall discussing other studies that pointed to the effectiveness of Chloroquine in the case of EGFRvIII about 3 years ago now. Seems there is some pretty solid evidence for CQ with EGFRvIII tumors.

    Chloroquine sensitizes MDA-MB-231 cells to osimertinib.
     
  10. AGA Guest

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