Plaquenil and retinal damage

Discussion in 'Hydroxychloroquine Sulfate' started by Crash AlekS, 14-Mar-2020.

  1. Berlingo Guest

    Plaquenil and retinal damage


    Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

    Plaquenil eye exam Chloroquine rxlist

    Although it is considered rare, retinal toxicity from the intake of Plaquenil can be irreversible even if the drug is discontinued 2, 3. What is Plaquenil Toxicity? The toxicity resulting from the intake of Plaquenil is due to its affinity for melanin-containing structures in the body. This sort of damage occurs only in 1 out of 5,000 people who take the drug for five years or more. You should see your ophthalmologist at least once per year so that she/he may check for retinal deposits. Retinal damage caused by hydroxychloroquine is generally reversible if caught early, but damage caused by chloroquine may not be. Screening requires the use of tests, such as 10–2 visual fields and SD-OCT and other modern techniques, such as autofluorescence imaging and multifocal electroretinography, to demonstrate early retinal damage.” 1 Melles & Marmor. The Risk of Toxic Retinopathy in Patients on Long-term Hydroxychloroquine Therapy.

    Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria.

    Plaquenil and retinal damage

    Has anyone had retinal damage from Plaquenil? - Lupus., Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus

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  7. Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy.

    • Retinal toxicity associated with chronic exposure to..
    • Plaquenil Risk Calculators.
    • The Risk of Retinal Toxicity with Plaquenil.

    Although the incidence of macular toxicity is infrequent with Plaquenil use at a dosage of 200mg or 400mg q.d. its visual impact can be devastating. 2,3. The associated classic retinal toxicity is described as a bull’s eye maculopathy ring of depigmented retinal pigment epithelium that spares the foveal area. Irreversible retinal damage has been observed in some patients who had received hydroxychloroquine sulfate. Significant risk factors for retinal damage include daily doses of hydroxychloroquine sulfate greater than 6.5 mg/kg 5 mg/kg base of actual body weight, durations of use greater than five years, subnormal glomerular filtration, use of some Plaquenil toxicity is typically asymptomatic in early stages, but over time can lead to severe vision loss and retinal damage. The risk of retinal toxicity was initially believed to be less than 1% after long-term or a cumulative dosage of 1,000mg. 3 The toxicity would double by 10 years, resulting in a 20% prevalence after 20 years. 4.

     
  8. Uniturs Moderator

    Hi All, Would like to know if anyone else has suffered darkening of the skin owing to this medication - I am a 'woman of colour' and have noticed a significant change in complexion and not a good look! Hydroxychloroquine Side Effects Common, Severe, Long Term. Hydroxychloroquine sulfate and Skin discoloration - bluish. Hydroxychloroquine-Induced Pigmentation in Patients With.
     
  9. Alexander997 Moderator

    Chloroquine - MedicScientist Total Health Portal Article Contents 1 Details About Generic Salt Chloroquine 2 Main Medicine Class Anti Infectives Sub Medicine Class Anti Malarials Details About Generic Salt Chloroquine Main Medicine Class Anti Infectives Sub Medicine Class Anti Malarials 12D. ANTI-RHEUMATIC DRUGS DMARDS in 12. MUSCULOSKELETAL DISORDERS & PAIN CHLOROQUINE 4-AMINOQUINOLINE ANTI-MALARIAL, ANTI-RHEUMATIC.

    Chloroquine Professional Patient Advice -
     
  10. MAZAY4ik Guest

    Hydroxychloroquine and hypoglycaemia Most people. - LUPUS UK My GP didn’t know of the connection between Hydroxychloroquine and hypoglycaemia. He is going to look into it though. In the meantime he has ordered a glucose blood test which will be done on Tuesday. What is concerning him though is my blood pressure is extremely low. Went over my medication and none of them would cause low blood pressure.

    Hydroxychloroquine - Wikipedia