Goldberg SB1, Supko JG, Neal JW, Muzikansky A, Digumarthy S, Fidias P, Temel JS, Heist RS, Shaw AT, Mc Carthy PO, Lynch TJ, Sharma S, Settleman JE, Sequist LV. Erlotinib with or without hydroxychloroquine in chemo-naive advanced NSCLC and (EGFR) mutations. Boston, MA: National Library of Medicine (US): 2009-2015. Stomach pain from plaquenil Dress syndrome hydroxychloroquine Hydroxychloroquine immunosuppressant Patient teaching on hydroxychloroquine Chloroquine has been shown to sensitise prostate cancer cells with a PTEN deletion to AKT inhibition by AZD5363 17, 48. In contrast, when we combined MK2206 and chloroquine in EGFR M+ NSCLC cells, this did not have any added benefit, but these cells are highly dependent on EGFR rather than AKT signaling for survival. The autophagy inhibitor chloroquine overcomes the innate resistance of wild-type EGFR non-small-cell lung cancer cells to erlotinib. Journal of Thoracic Oncology 86 693-702. Link here 2. Importantly, chloroquine-dependent mutant-EGFR protein level rescue was associated with recovery of receptor phosphorylation or mutant-EGFR–dependent signaling, as shown by the recovery of pERK and pAKT levels Fig. 2E–G; Supplementary Fig. S2C–S2F. We verified that the signaling rescue was not due to a nonspecific effect of chloroquine by cotreating cells with osimertinib, and results showed that pAKT and pERK rescue were still dependent on mutant-EGFR activation Supplementary Fig. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Since the pivotal trial evaluating the effect of temozolomide (TMZ), overall survival has not increased. National Insitute of Health; Massachusetts General Hospital. Chloroquine egfr Chloroquine Nivaquine, Resochin Healing Is Divine., Repurposing Drugs 101 - Chloroquine & Lung Cancer Severe side effects of plaquenilIf i go off plaquenil can i go back onPlaquenil pill dosesPlaquenil and low white blood count Jan 30, 2018 Stephen, I recall discussing other studies that pointed to the effectiveness of Chloroquine in the case of EGFRvIII about 3 years ago now. Seems there is some pretty solid evidence for CQ with EGFRvIII tumors. Our brain tumor cocktails and stories Chloroquine for GBM.. Reactivation of Mutant-EGFR Degradation through Clathrin.. Chloroquine - FDA prescribing information, side effects.. Methods To parse the autophagy–apoptosis crosstalk pathway as a potential targeted therapy in TNBC, the activity of an EGFR inhibitor, osimertinib, alone and in combination with an autophagy inhibitor, chloroquine, was examined in EGFR-overexpressing TNBC cell line, MDA-MB-231. The nature of interaction between both drugs at various. The Autophagy Inhibitor Chloroquine Overcomes the Innate Resistance of Wild-Type EGFR Non-Small-Cell Lung Cancer Cells to Erlotinib The EGFR inhibitor erlotinib is much less effective in NSCLC tumors with wild-type EGFR than in tumors with activating EGFR mutations. Autophagy is a tightly regulated lysosomal self-digestion process that may alternatively promote cell survival or type.