She started me on the generic version of Plaquenil at 200 mg. I have had extreme nausea, diarrhea, stomach cramps, and intense vertigo. I began taking it on Thanksgiving day and still experience these side effects. Effects of plaquenil on eyes Chloroquine injection use Plaquenil pour psoriasis Hydroxychloroquine sulphate overdose Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. The rheumatologist prescribed me the Plaquenil because I already have fatty liver disease. She said that plaquenil was the least likely to cause liver issues. I did read that there is a small possibility that was maybe the brand. Has anyone had a reaction to the generic. All of these medications can cause damage to the liver and increased liver enzymes. Let your physician know before starting these medications if you have any history of liver disease. Follow your physician’s prescription for these medications and have your liver enzymes tested on a regular basis. She cut my dose in half (100 mg) and that has partially helped the symptoms. A week ago I asked if there was anything we could do and she stated that this was the only treatment pill option. Can plaquenil cause liver problems Plaquenil and Brain Fog / Memory Issues / Anti RNP., Allergic reaction to Plaquenil Lupus Forums at The Lupus. Itching plaquenil Aug 14, 2017 According to Drugs.com, Plaquenil given for a long term can cause retinal disorders after a few months or years of daily use--especially if the dose exceeds 400mg per day. The risk of retinal damage increases at doses of 600mg to 700mg. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Rheumatoid Arthritis & Elevated Liver Enzymes Healthfully. Will you have Liver function test abnormal with Plaquenil.. Plaquenil and Acute kidney failure - from FDA reports Summary Acute kidney failure is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 1 - 2 years, also take medication Enbrel, and have Osteoporosis. According to Drugs.com, Plaquenil given for a long term can cause retinal disorders after a few months or years of daily use--especially if the dose exceeds 400mg per day. The risk of retinal damage increases at doses of 600mg to 700mg. Several risk factors may increase the likelihood of retinal toxicity from Plaquenil such as, age of greater than 60 years, daily dose more than 6.5 mg/kg; use of the drug more than 5 years, obesity, preexisting retinal disease and, renal or liver failure.