Chloroquine in cancer therapy a double edged sword of autophagy

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  1. REM_REM Guest

    Chloroquine in cancer therapy a double edged sword of autophagy

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    A potential target for cancer therapy is autophagy inhibition. Autophagy is a normal cellular response to stress in which organelles, cytoplasm, proteins, and metabolic by-products are degraded; this process is crucial to the survival and growth of apoptosis-deficient cancer cells. It is like a double-edged sword that can play either a protective or destructive role in cancer, by pro-survival. chloroquine, etc. are reported in pre-clinical and clinical study. in cancer therapy. Keywords Autophagy, cancer, ATG, ULK inhibitor, Vps34 inhibitor, mammalian target of rapamycin inhibitors. The emerging role of autophagy in cancer is one of a double-edged sword. On the one hand, autophagy enables tumor cells to tolerate stress including a hypoxic microenvironment, starvation, and probably some forms of therapy.

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    Chloroquine in cancer therapy a double edged sword of autophagy

    Chloroquine in Cancer Therapy A Double-Edged Sword of., Targeting autophagy with small molecules for cancer therapy

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  7. In particular, the autophagy inhibitors chloroquine and hydroxychloroquine, commonly used antimalarial drugs, are currently being investigated in phase I and phase II trials in patients with glioblastoma and myeloma. 6 In other studies, treatment of various cancer cells with small-molecule autophagy inhibitors, such as 3-methyladenine.

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    Cesses of autophagy is a more preferable approach in cancer therapy, however, and is now under investigation 28. Chloroquine in the Kidney, the Double-Edged Sword of Autophagy The use of chloroquine in combination with other chemo-therapeutic reagents may enhance cancer treatment 8, 29, but normal cells also use autophagy to maintain homeostasis, These findings are consistent with a secondary effect on bioenergetics by bafilomycin and chloroquine due to autophagy inhibition and a resulting decrease in mitochondrial quality. Y. IsakaChloroquine in cancer therapy a double-edged sword of autophagy. Cancer Res. 73 1 2013, pp. 3-7. Google Scholar. Evidence in favor of autophagy functioning as a tumor suppressor comes mostly from discoveries that inactivation of certain autophagy regulators causes cancer in mice and that some human tumors display loss of these regulators. For example, allelic loss of Becn1 causes increased tumor development in mice 22, 23.

  8. HATE User

    Hydroxychloroquine is in a class of drugs called antimalarials. Hydroxychloroquine MedlinePlus Drug Information Hydroxychloroquine DermNet NZ Hydroxychloroquine Plaquenil
  9. balishev XenForo Moderator

    The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. Comparative study of chloroquine and quinine on malaria. Chloroquine MedlinePlus Drug Information Chloroquine - Wikipedia
  10. lymnPlerielip New Member

    Plaquenil when allergic to sulfa? Lupus Forums at The. Plaquenil isn't a 'sulfa' drug which means a certain sort of antibiotic, the sulfonamides. Plenty of people who are allergic to those sulfa drugs take Plaquenil without any problem. This sounds all very odd to me!

    If you are allergic to sulfa drugs does this mean you can.
  11. rikler Guest

    Rx Side Effects New Plaquenil Guidelines and More. Plaquenil toxicity isn’t even in the top 10, or the top 100” if you’re looking at incidence, he said. “It’s a pretty rare thing.” Nevertheless, he urged doctors to master the Academy’s new guidelines, because the effects from chloroquine and hydroxychloroquine, when they do occur.

    Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.