I don't get many side effects generally, but with prednisone I DO. It does help, but this can't be a long term affair. Plaquenil is a great drug (I have no experience with it, but many people with lupus take it). I'd ask your rheumy about it and have them explain why they made that choice for you. Prednisone is an intermediate acting corticosteroid-which means it has direct anti-inflamitory properties that take effect begining in a few hours. Is plaquenil another option instead of the prednisone? It is ment to get this undercontrol now and diminish your pain. Plaquenil generic date Retinal thinning in plaquenil toxicity Hydroxychloroquine costco Chloroquine phosphate child's dosage malaria prophylaxis Summary Drug interactions are reported among people who take Prednisone and Plaquenil together. This study is created by eHealthMe based on reports of 13,794 people who take Prednisone and Plaquenil from Food and Drug Administration FDA, and is updated regularly. Plaquenil works well, but very slowly. You will need to give it at least a 6 months trial, and don't expect much in the way of results for a couple of months. After that, you'll probably look back and realize one day that you just don't feel as sore as you did three or four months back. The upside of prednisone is that it has the ability to control these flares by quickly alleviating the inflammation until other disease-modifying anti-rheumatic drugs DMARDs can take effect. While DMARDs like Plaquenil hydroxychloroquine and Arava leflunomide are more targeted in the control of the immune system, they are slower acting. It has not direct anti-inflamitory properties and instead works on the immune system-though the mechanism is not known. Plaq is a longer time medication it may take two months before their is a noticable difference. What time should i take my prednisone and my plaquenil Taking Plaquenil for Rheumatoid Arthritis, Plaquenil for RA?" Rheumatoid Arthritis Community. Chloroquine virus productionPlaquenil for scarring alopeciaIs hydroxychloroquine sulfate an immune suppressing drug I started taking plaquenil actually the generic form about a month ago. I have noticed that I am starting to feel less pain and not as tired. I take methotrexate 4 pills a week and prednisone 7.5 mg a day. My main concern is the side effect on the eyes with plaquenil. First time on Plaquenil -. Benefits and Risks of Prednisone - Verywell Health. Best time to take plaquenil - HealthBoards. My body was crashing hard with no sleep or food and basically a total water diet. I feel the dosage was way too high for someone my size, and with never taking it before, I regret it. I will never again take this pill for anything. At this point, my body hurts so bad; as if I’ve been taking it for a long period of time. I've been taking prednisone for my rheumatoid arthritis, but I've heard that it can increase my chances of developing osteoporosis. How big is the risk? Answer From April Chang-Miller, M. D. Generally, the higher the dose of prednisone you take and the longer you take it, the greater the risk of osteoporosis. However, even low doses interfere. The prednisone is a steriod and the plaquenil is a anti malaria drug. The thing with plaquenil for me is that I don't notice much of anything taking it but when I go off then I flare up and then really notice it. I have been taking the plaquinil for about 8 years morning and night and the prednisone off and on.