Information in these tables is updated regularly.4. Several medications are available for chemoprophylaxis. When deciding which drug to use, consider specific itinerary, length of trip, cost of drug, previous adverse reactions to antimalarials, drug allergies, and current medical history. Plaquenil increase liver enzymes Plaquenil and lupus nephritis Ra treatments plaquenil Malaria Information and Prophylaxis by Country; Country Areas with Malaria Drug Resistance 2 Malaria Species 3 Recommended Chemoprophylaxis 4 Key Information Needed and Helpful Links to Assess Need for Prophylaxis for Select Countries; Gabon All Chloroquine P. falciparum 90%, P. malariae, P. ovale, P. vivax 10% combined Although drug resistance has forced most malaria endemic countries to abandon chloroquine treatment for P. falciparum malaria, chloroquine remains the first line treatment for P. vivax malaria. This strategy is now under threat from the emergence and spread of chloroquine resistant P. vivax 2, 6-7. Resistance of P. vivax to chloroquine has been confirmed only in Papua New Guinea and Indonesia. For destinations where any chloroquine-resistant malaria is present, in addition to mosquito avoidance measures, prophylaxis options are atovaquone-proguanil, doxycycline, mefloquine, and tafenoquine. This risk estimate is based largely on cases occurring in US military personnel who travel for extended periods of time with unique itineraries that likely do not reflect the risk for the average US traveler.6. All travelers should seek medical attention in the event of fever during or after return from travel to areas with malaria.5. Chloroquine resistant malaria vivax Malaria - Wikipedia, Plasmodium vivax and drug resistance Worldwide Antimalarial. Weight gain with plaquenilPlaquenil tooth decay Although chloroquine-resistant P. falciparum predominates in Africa, it is found in combination with chloroquine-sensitive P. vivax malaria in South America and Asia. Resistance of P. vivax to chloroquine has been confirmed only in Papua New Guinea and Indonesia. For destinations where any chloroquine-resistant malaria is present, in addition. Malaria - Chapter 4 - 2020 Yellow Book Travelers' Health CDC. Malaria - Chapter 4 - 2020 Yellow Book Travelers' Health.. CDC - Malaria - Diagnosis & Treatment United States.. The resistance of Plasmodium vivax to chloroquine has become an obstacle to control strategies based on the use of anti-malarials. The current study investigated the association between P. vivax CQ-resistance in vivo with copy number variation and mutations in the promoter region in pvcrt-o and pvmdr1 genes. The study included patients with P. vivax that received supervised treatment with. In Pakistan, Plasmodium vivax contributes to major malaria burden. In this case, a pregnant woman presented with P. vivax infection and which was not cleared by chloroquine, despite adequate treatment. This is probably the first confirmed case of chloroquine-resistant vivax from Pakistan, where severe malaria due to P. vivax is already an emerging problem. Chloroquine resistance in Plasmodium vivax has also now arisen, though more recently—the first reports came from 1989, in Australia, in travellers returning from Papua New Guinea. Now, chloroquine resistant forms of P. vivax are found in multiple locations in south-east Asia, such as Myanmar and India, as well as from Guyana in South America.