Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Chloroquine dose for malaria prophylaxis Dr bhat plaquenil Jan 01, 2011 Fundus autofluorescence is a noninvasive, rapid and potentially useful imaging modality that continues to evolve. FAF reflects metabolic changes in the RPE and thus provides an assay of retinal and RPE function. FUNDUS AUTO FLUORESCENCE The fundus auto fluorescence confirms Plaquenil toxicity, worse in the left eye than the right eye with an area in the right eye of hyperfluorescence in the macula and the left eye there is an area of hypofluorescence in the macula. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Fundus autofluorescence plaquenil Clinical applications of fundus autofluorescence in., Plaquenil Toxicity - Mild - Partial Bull's Eye Maculopathy. Plaquenil herx symptomsChloroquine diphosphate useSarcoidosis treatment usmle hydroxychloroquineHydroxychloroquine related rash on external genitali Fundus Autofluorescence FAF Early hydroxychloroquine toxicity can also be detected on autofluorescence as an increased ring of signal within the parafoveal and extramacular regions, which is indicative of photoreceptor dysfunction and RPE dysfunction. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Recommendations on Screening for Chloroquine and.. Autofluorescence Retina Test Mid Atlantic Retina. Dec 04, 2014 This baseline evaluation entails a dilated fundus examination, 10-2 white pattern visual field test subjective, and at least one of the following objective tests Spectral-domain optical coherence tomography SD-OCT, fundus autofluorescence FAF, or multifocal electroretinogram mfERG. A normal fundus autofluorescence does not rule out toxic maculopathy. Optical coherence tomography and multifocal electroretinography seem to be more sensitive in the early stage of the disease. In case of typical complaints and visual fields, the optical coherence tomography has to be evaluated for subtle alterations of the outer retina. At right, FAF image shows large soft drusen associated with increased fundus autofluorescence in a patchy FAF pattern. There are also more defined areas of hyper-AF corresponding to mixed drusen in a focal increased pattern superior and inferior to the fovea.