It is an electrical disturbance which can be seen on an electrocardiogram (ECG). Excessive QT prolongation can trigger tachycardias such as Torsades de Pointes (Td P). Is atovaquone a chloroquine Hydroxychloroquine dose Chloroquine is associated with an increased risk of QT prolongation and torsade de pointes TdP; fatalities have been reported. The risk of QT prolongation is increased with higher chloroquine doses. QT prolongation has occurred during therapeutic use of atomoxetine and following overdose. Although it isn't mentioned specifically, I believe QT prolongation is the main cause of death in several other suicide methods, such as chloroquine,amilityprine OD as well as hypothermia. Knowing this will give you a better understanding of why these methods lead to death and how you can improve upon them when you are to carry it out. Drugs to avoid. Anyone with a condition affecting the heart that can cause sudden cardiac death needs to take extra care with medicines. All medicines – both those prescribed by your doctor and any you buy over the counter – must be checked, as some can increase the risk of sudden death. On an EKG, the QT interval represents the summation of action potentials in cardiac muscle cells, which can be caused by an increase in inward current through sodium or calcium channels, or a decrease in outward current through potassium channels. QT prolongation is an established side effect of anti-arrhythmic medicines, but can also be caused by a wide range of non-cardiac medicines, including antibiotics, antihistamines, opioid analgesics and complementary medicines. Chloroquine qt prolongation Chloroquine - FDA prescribing information, side effects and uses, Inducing QT Prolongation and Sudden Death Sanctioned Suicide Para q sirve el hydroxychloroquine 200 mgPlaquenil antibiotic QT prolongation is a measure of delayed ventricular repolarisation, which means the heart muscle takes longer than normal to recharge between beats. It is an electrical disturbance which can be seen on an electrocardiogram ECG. Excessive QT prolongation can trigger tachycardias such as Torsades de Pointes TdP. Drug-induced QT prolongation - Wikipedia. Drugs to avoid. Drugs and the QT Interval – What Do Pharmacists Need to Know?. Acute HCQ poisoning has been reported to cause a prolonged QT interval, hypokalaemia and a prolonged QRS complex. RA itself is an independent risk factor for cardiovascular CV disease and a recent study has shown that patients are 40% more likely to develop atrial fibrillation. QT prolongation, a surrogate marker for the risk of developing TdP, is an established side effect of Class I and Class III anti-arrhythmic medicines. It is also a rare side effect of a wide range of non-cardiac medicines including some antibiotics, antihistamines, opioid analgesics and complementary medicines. What is QT prolongation? Chloroquine can also prolong the QT interval and cause long QT syndrome. Some of the antibiotics are also known for increase in the QT interval. Clarithromycin and erythromycin have the side effects of prolonging QT interval. Antihistamines such as loratadine and diphenhydramine also trigger the prolonged QT interval.