Plaquenil toxicity cumulative dose

Discussion in 'Cheap Chloroquine' started by EGM, 05-Mar-2020.

  1. SmigneeOpennaa Moderator

    Plaquenil toxicity cumulative dose


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    The risk of this happening is highly correlated with the cumulative dose of the drug you have received. So, the higher the dose and the longer you have been on it the higher your risk. The current recommendation is a daily dose that does not exceed 6.5 mg/kg/day that is milligrams per kilograms per day. There are approximately 2.2 lbs. in a KG. The incidence of retinal toxicity is associated with the cumulative dose of the drug, increasing significantly beyond 1,000 g of HCQ. This cumulative dose is created when the common dose of 400 mg/day is used for 6.8 years. Hydroxychloroquine is metabolized and secreted by both the liver and the kidneys. The same study revealed that the most important predictor of toxicity was the duration of use cumulative dose and that age, the daily dose, and patient weight did not correlate significantly with HCQ toxicity. One reaches a cumulative dose of 1000 grams 1 kilogram at 7 years when taking the most commonly prescribed dose of 400 mg a day.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Plaquenil toxicity cumulative dose

    New Plaquenil Guidelines, Retinal Physician - Hydroxychloroquine Maculopathy An.

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    Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Daily dose greater than 400 mg or, in people of short stature, a daily dosage over 6.5 mg/kg ideal body weight or total cumulative dose of more than 1,000 g ; medication use longer than five years ; concomitant renal or liver disease because the drug is cleared by both routes underlying retinal disease or maculopathy ; age greater than 60 years. Plaquenil Toxicity. dlrobards posted. While 2002 AAO guidelines emphasized the importance of not exceeding daily dose of 6.5mg/kg body weight, the cumulative dose was not identified as an independent risk factor. Since then, published data indicates that a total dose of 1000 grams should be considered as a risk factor.

     
  6. GoldInc XenForo Moderator

    Also known as: Plaquenil, Quineprox The following information is NOT intended to endorse any particular medication. Clarithromycin and hydroxychloroquine Plaquenil. Hydroxychloroquine User Reviews for Lyme Disease, Arthritis at Clarithromycin and hydroxychloroquine Plaquenil - LymeNet.
     
  7. ArendProdektr Moderator

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  8. Studiopromo XenForo Moderator

    Pharmacological modulation of autophagy therapeutic. Nature Reviews Drug Discovery volume 16. Cui, C. M. et al. Chloroquine exerts neuroprotection following traumatic brain injury via suppression of inflammation and neuronal autophagic death.

    Chloroquine Aralen - Side Effects, Dosage, Interactions.