Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Plaquenil nail discoloration Can you have alcohol while taking plaquenil Plaquenil and cotrimoxazole Hydroxychloroquine gh The risk of this happening is highly correlated with the cumulative dose of the drug you have received. So, the higher the dose and the longer you have been on it the higher your risk. The current recommendation is a daily dose that does not exceed 6.5 mg/kg/day that is milligrams per kilograms per day. There are approximately 2.2 lbs. in a KG. The incidence of retinal toxicity is associated with the cumulative dose of the drug, increasing significantly beyond 1,000 g of HCQ. This cumulative dose is created when the common dose of 400 mg/day is used for 6.8 years. Hydroxychloroquine is metabolized and secreted by both the liver and the kidneys. The same study revealed that the most important predictor of toxicity was the duration of use cumulative dose and that age, the daily dose, and patient weight did not correlate significantly with HCQ toxicity. One reaches a cumulative dose of 1000 grams 1 kilogram at 7 years when taking the most commonly prescribed dose of 400 mg a day. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil toxicity cumulative dose New Plaquenil Guidelines, Retinal Physician - Hydroxychloroquine Maculopathy An. Hydroxychloroquine and drinking alcoholChloroquine phosphate fishHydroxychloroquine for lupus nephritis Usual Adult Dose for Malaria Prophylaxis. Suppression 400 mg 310 mg base orally on the same day every week Comments-Suppressive therapy should begin 2 weeks prior to exposure; however, failing this, an initial dose of 800 mg 620 mg base may be taken in 2 divided doses 6 hours apart. Hydroxychloroquine Dosage Guide with Precautions -. Chloroquine And Hydroxychloroquine Toxicity - StatPearls.. Protecting your eyesight when taking Plaquenil Lupus.. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Daily dose greater than 400 mg or, in people of short stature, a daily dosage over 6.5 mg/kg ideal body weight or total cumulative dose of more than 1,000 g ; medication use longer than five years ; concomitant renal or liver disease because the drug is cleared by both routes underlying retinal disease or maculopathy ; age greater than 60 years. Plaquenil Toxicity. dlrobards posted. While 2002 AAO guidelines emphasized the importance of not exceeding daily dose of 6.5mg/kg body weight, the cumulative dose was not identified as an independent risk factor. Since then, published data indicates that a total dose of 1000 grams should be considered as a risk factor.