So far I have no more energy than when I first started and has developed neuropathy which I have just found out from Web MD that this neuropathy is one of the side effects of this med! Saying that by stopping this it would take another 6 months to build up the benefit. There are other meds that can help with what you are experiencing, and if your doctor didn't address that then I would seek out a second opinion... Please don't stop your plaquenil until you are sure it is the right thing to do and in your best interest. Plaquenil and cyclosporine Chloroquine mechanism of action in rheumatoid arthritis Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up. When allowed to advance, hydroxychloroquine retinal toxicity leads to loss of up to three visual functions acuity, peripheral vision and night vision. Signs. On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull. I have been on plaquenil for a while now and have started to have blurred vision. I have been to my eye doc. twice and all tests are normal. Should I continue to take it, I know that it can cause eye problems but my doc. says that it is very rare. Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. Or maybe another doctor if you're not comfortable w/your current one. Plaquenil blurry vision years after stopping Long-Term Side Effects of Plaquenil for Rheumatoid., Hydroxychloroquine-Induced Retinal Toxicity - American. Does hydroxychloroquine thin blood Plaquenil-induced toxicity usually will not occur before five years of taking the drug. “Eye damage due to Plaquenil is not common,” he says. “Rarely will anybody who has good vision and minimal symptoms develop loss of central vision or ability to read if annual screening is done and visual are symptoms reported as soon as they occur so the medication can be stopped if toxicity occurs. Protecting your eyesight when taking Plaquenil Lupus.. Plaquenil and blurred vision.. Medications that can Affect the Eye or Visual System. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. One of the side effects of taking the drug is that it affects eye sight, and eye tests, especially field of vision tests need to be done every six months. For the four years that I took the drug, my eye sight never bothered me and bi-annual eye tests revealed no changes. My son his on Plaquenil and he complained about Constant pain and worse when bending forward. He compares the pain to that of a small pericarditis. He do all of his day at school including sports but the plain is always there. The pain started about 1 month after he began to take Plaquenil hydroxychloroquine.