While there is good clinical evidence demonstrating the drug’s efficacy in rheumatoid arthritis and lupus, there are very few studies looking at hydroxychloroquine as a treatment for Sjögren’s. The studies that do exist show mixed results (some show Nonetheless, despite the lack of clinical studies, rheumatologists feel that hydroxychloroquine may have a potential beneficial effect in helping patients with symptoms of fatigue and achiness, which are common complaints in patients with Sjögren’s. Chloroquine hydrochloride properties Chloroquine antibody Reviews and ratings for plaquenil when used in the treatment of rheumatoid arthritis. I rated it an 8 because I do not feel sick after taking it and it does seem to work. "This medication did wonders for my soreness and pain from Rheumatoid Arthritis but if someone would have told me I would have devastating and. Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus. Plaquenil does help with some of the symptoms of Lupus, but it does take a few weeks to start helping. It's most important role is to inhibit progression of the disease -- I'm really surprised you haven't been on it ever since the Lupus was diagnosed. The good news is that hydroxychloroquine targets the immune system without causing an increase in the risk of infection or cancer that can be seen with other immunosuppressant medications. How the drug works is unclear, but recent research has pointed to an inhibitory effect on toll-like receptors that are proteins involved with inflammation. What if plaquenil doesn t work Plaquenil User Reviews for Rheumatoid Arthritis at, Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus. Chloroquine and primaquine doseChloroquine hair loss Jun 09, 2012 I have also tried hydroxychloroquine and sulfazalazine both of which caused tinnitus so had to come off them. My consultant has now put my methotrexate up to 25mg to see if my symptoms improve. I'm trying to stay positive but if this doesn't work what other treatment is there. it is so annoying as the combination of methotrexate and. RA - what else can I try, now on methotrexate, have tried.. Lupus & Plaquenil/Pain -. Plaquenil and corona lupus. Last week my doc added plaquenil to the mix. I have a pharmacist friend that says it can take up to a year to work, but once its kicks in it can be really good. I suggest you ask your rhuemie for additional help in the meantime. I have had RA going on 12 years, and originally way back when I ws given plaquenil alone and it did nothing. Re Plaquenil vs. Methotrexate Hello, I take Plaquenil but I found that I had to take it with Prednisone for the first 2 months until it started to work. I went off of the Predisone after one month but the pain came back so I took it another month and then quit and the Plaquenil worked great and still does. Mar 24, 2011 no methotrexate doesn't always mean your hair will fall out or thin but some of the side effects are scary, but before you an progress onto other meds methotrexate is mandatory. for me methotreaxte and plaquenil does't work and i' intonate of sulfa so i am started embrel which states you have to have tried 2 of 3 meds and methotrexate is 1 of them.