Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Is hydroxychloroquine safe Hydroxychloroquine sulphate tablets uses Plaquenil and heart rate Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine, or a combination of the three medications Results of a two‐year, randomized, double‐blind, placebo‐controlled trial I am on both methotrexate and plaquenil. I have been on plaquenil for over a year and a half and methotrexate since September. I have had no side effects from either one. I get my eyes checked every six months and I am now at once a month on blood work for my liver enzymes used to be every 2 weeks. OBJECTIVE To examine the bioavailability of methotrexate MTX in the presence of hydroxychloroquine HCQ, and vice versa, to determine a possible pharmacokinetic explanation for the observation that combination treatment of rheumatoid arthritis with MTX and HCQ has been shown, clinically, to be more potent than MTX used alone. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Combination of plaquenil and methotrexate Methotrexate monotherapy and methotrexate combination therapy., Which would you pick and why? - Plaquenil or Methotrexate Taking plaquenil and sun exposure This study evaluates the efficacy of the combination of methotrexate and hydroxychloroquine against leflunomide, a new DMARD as initial therapy in severe active rheumatoid arthritis. Hydroxychloroquine is known to increase the potency of methotrexate as well as increase its safety profile and reduce the dose. Evaluation of efficacy of combination of methotrexate and.. Combination therapy with methotrexate and hydroxychloroquine.. Plaquenil hydroxychloroquine sulfate dose, indications.. Methotrexate–hydroxychloroquine combination therapy may cause lower disease activity in early RA than methotrexate monotherapy. Methotrexate monotherapy as first early RA treatment seems to lead to more treatment intensification. Combined use of methotrexate with gold, penicillamine, hydroxychloroquine, sulfasalazine, or cytotoxic agents, has not been studied and may increase the incidence of adverse effects. Rest and physiotherapy as indicated should be continued. Methotrexate is available under the following different brand names Trexall, Otrexup, and Rasuvo. Learn about drug interactions between hydroxychloroquine oral and methotrexate sodium oral and use the RxList drug interaction checker to check drug combinations.