It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Does plaquenil cause heartburn Plaquenil class Chloroquine phosphate 250 mg side effects Does plaquenil make you tired Dec 15, 2010 hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. Feb 19, 2020 What Are Side Effects of Plaquenil? nausea, vomiting, stomach pain or cramps, loss of appetite, weight loss, diarrhea, dizziness, spinning sensation, headache, ringing in your ears, I was on both medis for 15 years for mixed connective disease. I recently stopped methotrexate due to lungs involvement, my pulmonologist decided to put me on cellcept.i had no majors side effects but a metal taste when I first started. Make sure you have a chest X-ray yearly and periodic labs work. Good luck. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. Side effects of plaquenil and methotrexate Hydroxychloroquine Side Effects, Dosage, Uses, and More, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Hydroxychloroquine syrupWhat are the side effects of taking plaquenil Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Reduces inflammation and cell replication. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Compare Plaquenil vs Methotrexate -. Methotrexate and plaquenil - @Kristinsaba1988.. Side effects plaquenil/methotrexate. rheumatoid. I do know that plaquenil is generally considered the least invasive drug, generally prescribed as the first line of treatment. Methotrexate is the most commonly prescribed DMARD, but it does come with the chance of side-effects. I never had any side-effects of dire consequence, but many on this forum have. Call your doctor immediately or get emergency medical help if you experience any of the following serious side effects Any vision problems, such as reading difficulties, sensitivity to light, seeing light flashes or streaks, blurred distance vision, or other issues Hearing problems. Side-effects aren't common. However, in some people hydroxychloroquine can cause skin rashes, especially those made worse by sunlight; feeling sick nausea or indigestion; diarrhoea; headaches; bleaching of the hair or mild hair loss; tinnitus ringing in the ears visual problems.