Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Mix chloroquine phosphate and metroplex Plaquenil toxicity screening May 02, 2007 Yes, it is standard to have an ophthalmologist exam every 6 mths or 1 yr when taking Plaquenil. My rheumy says 1 yr is ok, as problems very seldom develop. I don't know of anyone here who has had any problems. If you do have problems, with the 1 yr exam they will be caught and are reversible by stopping the plaquenil. At the recommended dose, development of visual problems due to the medication is rare. It is recommended that you have an eye exam within the first year of use, then repeat every one to five years based on current guidelines. Retinopathy can lead to sight loss so it’s important that you keep your doctor informed of any changes you experience in your vision. If you are using Plaquenil, The Wellish Vision Institute recommends regular eye exams to help catch any change that may be subtly occurring. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil eye exam how often Plaquenil/Hydroxychloroquine - which eye tests do. - LUPUS UK, Hydroxychloroquine Plaquenil Plaquenil full life There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Risk of Toxicity The risk of toxicity is dependent on daily dose and duration of use. At recommended doses, the risk of toxicity up to 5 years is under 1% and up to 10 years is under 2%. Recommendations on Screening for Chloroquine and.. Plaquenil - Wellish Vision Institute. The Risk of Retinal Toxicity with Plaquenil. Hydroxychloroquine Plaquenil was originally used to treat malaria and is now used mostly to treat rheumatological and dermatological diseases. Its most frequent use now is for Rheumatoid Arthritis RA and Lupus and is often very effective in mitigating the joint and arthritic symptoms these diseases can cause. The risk is much higher in patients who have been taking the drug for 20 years or more. In these patients between 20 and 50 out of 100 will develop retinopathy. At this appointment, a number of photographs and scans will be taken of your retina to assess your eye health and your suitability for screening. Risk for toxicity is least with less than 6.5 mg/kg/day for hydroxychloroquine and 3 mg/kg/day for chloroquine. Patients are at low risk during the first 5 years of treatment. Cumulative use in excess of 250 grams increases the risk for toxic retinopathy. Other risk factors include obesity, kidney or liver disease, older age.