Chloroquine treatment of amoebic liver abscess

Discussion in 'Canadian Drug' started by ali82, 24-Feb-2020.

  1. n0b0dy XenForo Moderator

    Chloroquine treatment of amoebic liver abscess


    After completion of treatment with tissue amebicides, administer luminal amebicides for eradication of the asymptomatic colonization state. Failure to use luminal agents can lead to relapse of infection in approximately 10% of patients.

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    Chloroquine and metronidazole were compared in a randomized trial for the treatment of amoebic liver abscess in 36 patients. An additional 30 patients were treated without randomization. Rarely, when patients of amoebic liver abscess are vomiting, injection chloroquine can be used in a dose of 0.3–0.6 G. base in 24 hours not exceeding 0.9 G. Chloroquine given alone is a safer drug than emetine in amoebic liver abscess, but unfortunately the relapse rate is almost 25%. Amebic liver abscess is the most frequent extraintestinal manifestation of Entamoeba histolytica infection. This infection is caused by the protozoa E histolytica, which enter the portal venous system from the colon.

    The details on tissue and luminal amebicidal agents are discussed in Medication. In general, metronidazole, tinidazole, emetine, and dehydroemetine are active in invaded tissues; chloroquine is active only in the liver; tetracycline acts on the bowel wall; and diloxanide furoate, paromomycin, and iodoquinol are luminal agents only.

    Chloroquine treatment of amoebic liver abscess

    Comparison of Metronidazole and Chloroquine for the Treatment., Amoebic liver abscess - Wikipedia

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  7. Amebic Liver/Hepatic Abscesses Medication. Updated Oct 15, 2019 Author. In vitro studies with trophozoites of E histolytica demonstrate that chloroquine possesses amebicidal activity comparable to that of emetine. Highly effective in the treatment of amebic liver abscess when administered with emetine or dehydroemetine. et al. Treatment.

    • Amebic Liver/Hepatic Abscesses Medication Amebicides.
    • Amebic Liver/Hepatic Abscesses Treatment & Management Medical Care..
    • Chloroquine in the Treatment of Amoebic Liver Abscess - Europe PMC..

    Negative titres exclude amoebic abscess as a diagnostic possibility. Diagnosis is 100% confirmed by aspiration of liver abscess, anchovy sauce is quiet diagnostic Sigmoidoscopy reveals characteristic amoebic ulcers Radiography often reveals elevation and fixation of right half of diaphragm Liver function tests and examination of stool for. Comparison of metronidazole and chloroquine for the treatment of amoebic liver abscess. A controlled trial. Cohen HG, Reynolds TB. Chloroquine and metronidazole were compared in a randomized trial for the treatment of amoebic liver abscess in 36 patients. An Chloroquine in the Treatment of Amoebic Liver Abscess. HARINASUTA C. Chloroquine in the treatment of amoebic liver abscess. Ind Med Gaz. 1950 Feb; 85 237–41.

     
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