While the mechanism is poorly understood, pregnant women have a reduced immune response and therefore less effectively clear malaria infections. In addition, malaria parasites sequester and replicate in the placenta. Plaquenil and quinine Mechanism of action of chloroquine in malaria Plaquenil and sulfasalazine combination Animal studies have revealed evidence of fetal harm. Use of chloroquine and other 4-aminoquinolines in high doses and for prolonged durations has been associated with neurological disturbances and interference with hearing, balance, and vision in the fetus. There are no controlled data in human pregnancy. Symptomatic and asymptomatic malaria infections during the first trimester of pregnancy were associated with miscarriage; treatment appeared to be safe. Malaria during pregnancy has adverse effects, including maternal mortality, miscarriage, and low birthweight. Chloroquine Phosphate. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Malaria infection during pregnancy can lead to miscarriage, premature delivery, low birth weight, congenital infection, and/or perinatal death. Pregnant women are three times more likely to develop severe disease than non-pregnant women acquiring infections from the same area. Is chloroquine safe during pregnancy Safety of hydroxychloroquine in pregnant patients with., First-Trimester Malaria Treatment and Outcomes What does chloroquine treatUsing chloroquine to treat glioblastomaDoes hearing loss from plaquenil come backGray nails and plaquenilHydroxychloroquine sickle cell Sunday, 01 July 2018. In every pregnancy, a woman starts out with a 3-5% chance of having a baby with a birth defect. This is called her background risk. This sheet talks about whether exposure to hydroxychloroquine may increase the risk for birth defects over that background risk. Hydroxychloroquine MotherToBaby. Chloroquine Oral Uses, Side Effects, Interactions.. Methotrexate and Pregnancy Is It Safe If You Have RA?. Summary. Aralen is the brand name for the generic drug chloroquine, an anti-malaria drug used to treat malaria and amebiasis infection that's spread outside of the intestines. Dosage, drug interactions, and pregnancy and breastfeeding safety information should be reviewed prior to taking this drug. A body of clinical experience suggests chloroquine is safe during pregnancy and improves outcome in women with active disease. In one study of 96 women with active malaria, chloroquine 10 mg/kg was given at time 0 and 24 h and again at 48 h 5 mg/kg. Chloroquine and mefloquine are the drugs of choice for pregnant women for destinations with chloroquine-sensitive and chloroquine-resistant malaria, respectively. Doxycycline is contraindicated because of teratogenic effects on the fetus after the fourth month of pregnancy.