Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine authophagy Plaquenil eye effects Yes, plaquenil can cause low blood sugars. Eat frequent meals with carbs and protein but good carbs with fiber like oatmeal or whole wheat toast with peanut butter. I like the lowered blood sugar effect b/c I have type 2 diabetes but before I got type 2, I had some low sugars with plaquenil for sure. What Is Plaquenil? Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. What Are Side Effects of Plaquenil? Context Hydroxychloroquine, a commonly used antirheumatic medication, has hypoglycemic effects and may reduce the risk of diabetes mellitus. Objective To determine the association between hydroxychloroquine use and the incidence of self-reported diabetes in a cohort of patients with rheumatoid arthritis. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil and hypoglycemia Plaquenil Side Effects Common, Severe, Long Term -, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Plaquenil toxicity retinaHow long is plaquenil potent good for Plaquenil and Hypoglycemia Yesterday I was cruising around on the Sjogren's World Forum and came across an interesting topic of discussion. One of the sjoggies there who is diabetic noted that her blood sugars were consistently lower after she began taking Plaquenil hydroxychloroquine. Reasonably Well Plaquenil and Hypoglycemia. Hydroxychloroquine and Risk of Diabetes in Patients With.. Plaquenil hydroxychloroquine sulfate dose, indications.. I never did take plaquenil when it was offered by the rheumatologist, mainly because I had serious shingles which affected my eyes and I was afraid to take anything that might cause more problems with my eyes at the time. Anyway, that is beside the point but looking at the pharmacy company's write-up on plaquenil there is a statement that says Antimalarials such as hydroxychloroquine HCQ, are among the oldest prescribed drugs still used in clinical practice. Relatively inexpensive and well tolerated, these drugs have been recognized to be effective in autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythematosus SLE. Suicidal behavior has been rarely reported in patients treated with PLAQUENIL. Hypoglycemia. PLAQUENIL has been shown to cause severe hypoglycemia including loss of consciousness that could be life threatening in patients treated with or without antidiabetic medications see DRUG INTERACTIONS and ADVERSE REACTIONS. Patients treated with.