Additionally, another exception occurred while executing the custom error page for the first exception. Ototoxicity is, quite simply, ear poisoning (oto = ear, toxicity = poisoning), which results from exposure to drugs or chemicals that damage the inner ear or the vestibulo-cochlear nerve (the nerve sending balance and hearing information from the inner ear to the brain). Can plaquenil affect your thyroid Chloroquine ireland Plaquenil 200mg dosage Chloroquine phosphate in pregnancy The present study provides the first evidence for the occurrence of autophagy and its role in cisplatin-induced ototoxicity. In conclusion, autophagy plays a pro-death role in cisplatin-induced ototoxicity via mTOR pathway, and modulating the autophagic pathway might be another strategy against cisplatin-induced ototoxicity. Ototoxicity, drugs, chemicals, mobile phones and deafness MK Taneja 1, Himanshu Varshney 2, Vivek Taneja 1, Jitendra Varshney 3 1 Senior ENT and Head Neck Surgeon, Indian Institute of Ear Diseases, New Delhi, India 2 ENT Surgeon; Sri Sai Hospital, Moradabad, Uttar Pradesh, India 3 Sri Sai Hospital, Moradabad, Uttar Pradesh, India Antimalarials- Quinine & Chloroquine- Ototoxic effect is due to vasoconstriction in the small vessels of the cochlea and stria vascularis.- The effect is reversible which generally appears on prolonged medication, but deafness is permanent with chloroquine.- The parts of the brain that receive hearing and balance information from the inner ear can also be affected by poison, but this is not technically considered ototoxicity and won’t be covered in this information sheet. Because the inner ear is involved in both hearing and balance, ototoxicity can result in disturbances of either or both of these senses. Chloroquine ototoxicity Preventing Hearing Loss Caused by Chemical Ototoxicity and Noise Exposure, Ototoxicity, drugs, chemicals, mobile phones and deafness. Can plaquenil cause sun sensitivityQuinacrine with hydroxychloroquinePlaquenil full lifeDoes plaquenil reduce pain Ototoxicity is typically associated with bilateral high-frequency sensorineural hearing loss and tinnitus. Hearing loss can be temporary but is usually irreversible with most agents. Generally, antibiotic-induced ototoxicity is bilaterally symmetrical, but it can be asymmetrical. Ototoxicity Overview, Aminoglycosides, Other Antibiotics. Ototoxicity - SlideShare. Chloroquine - Wikipedia. The ototoxic effects can be minimized by carefully monitoring blood levels. Quinine • chloroquine phosphate Aralen • quinacrine hydrochloride Atabrine • quinine sulfate Quinam The ototoxic effects are very similar to those of aspirin. Mucosal Protectant • misoprostol Cytotec Narcotic Analgesics • hydrocodone Lorcet, Vicodin Chloroquine CQ, a 4-aminoquinoline drug, has been largely used for the treatment of rheumatoid arthritis and other connective tissue diseases. Besides the well-known retinal toxicity, its use has been suspected of be associated to ototoxicity. Some reports have described mainly sensorineural hearing loss, tinnitus, sense of imbalance, and cochleovestibular manifestations. Differently from. This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative.