If so, would you share a comment on the experience you have had with methotrexate; & the length of time on the medication, benefits noted, and side effects. It can be brief or as detailed as you desire to describe your experience. I used plaquenil for some time on its own, then added in MTX before changing over to leflunomide. Pain medication plaquenil Hydroxychloroquine reviews eyes Plaquenil dosage forms Chloroquine and alcohol consumption Plaquenil hydroxychloroquine "I’ve been on plaquenil 400mg once a day for 6 months now due to Sjogrens. If your are wondering how long the plaquenil takes to work, it took about 3 months before I starting feeling better. The news has been buzzing about Venus Williams dropping out of the US Open because of Sjogren's syndrome. As the media has discussed, Sjogren's is an autoimmune disease that attacks the tear and salivary glands and generally results in widespread dryness in the body. In addition to dry eyes and. Plaquenil or Methotrexate? Support Forums Sjogren's Syndrome. And, Plaquenil takes 2-3 months to build up in your system. So in the event that you are one of the people who is actually able to notice a difference in symptoms, you may not notice them for 2-3 months. I would have stayed on MTX if it worked for me, but it didn’t. I didn’t drop plaquenil until I had been on a biologic for about six months. Plaquenil and methotrexate for sjogren's syndrome Sjogren's diagnosis - prescribed Plaquenil?, Why There's More to Sjogren's Syndrome The Dr. Oz Show Plaquenil palindromic rheumatismInappropriate malaria prophylaxis chloroquine resistantLupus fog plaquenil Does anyone use methotrexate just for their Sjogrens symptoms? If so, would you share a comment on the experience you have had with methotrexate; & the length of time on the medication, benefits noted, and side effects. Sjogren's Syndrome Support. Methotrexate opinions. Symptoms and Medical Treatments _Lisa_D. I used plaquenil for some. Methotrexate opinions - Symptoms and Medical Treatments.. Plaquenil or Methotrexate? -. Plaquenil side effect, loss of appetite - Sjogren's Syndrome.. Nov 29, 2018 A combination of leflunomide and hydroxychloroquine significantly reduced disease activity, increased salivary flow, and improved patient-perceived health in patients with primary Sjögren’s syndrome, a pilot trial showed. Findings of the trial were revealed at the recent American College of. Plaquenil hydroxychloroquine is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. Plaquenil hydroxychloroquine "I have been on this medication for approximately 8 years. Before I started this medicine I was in terrible shape. With Sjogren's syndrome as my primary autoimmune disease and rheumatoid arthritis as my secondary autoimmune disease I was in terrible persistent pain.